A comparative study of cyclosporine and its derivative SDZ IMM-125 in canine renal allografts.

作者信息

Watson C J, Metcalfe S M, St John Collier D G, Calne R Y

机构信息

University Department of Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom.

出版信息

Transplantation. 1993 Nov;56(5):1248-50. doi: 10.1097/00007890-199311000-00038.

The immunosuppressive efficacy of CsA and its derivative SDZ IMM-125 was compared in highly mismatched mongrel dogs in receipt of renal allografts. At an equal dose of 15 mg/kg/day and in the same drug vehicle, SDZ IMM-125 was not superior to CsA in prolonging allograft survival. Whole blood levels of SDZ IMM-125 were lower than those achieved for CsA. No specific drug-related side effects were noticed in this model.