Haczyński J, Spring A
Katedry i Kliniki Kardiologii Ak. Med., Wrocławiu.
Wiad Lek. 1993 Apr;46(7-8):241-4.
The effect was studied of 8 weeks of treatment with propranolol and pindolol on the left-ventricular myocardium mass, left-ventricular myocardium mass index, plasma renin activity, and serum aldosterone and total catecholamine concentrations. The studies were carried out in 72 patients with essential arterial hypertension of slight degree. A statistically significant decrease was shown of the left-ventricular myocardium mass, left-ventricular myocardium mass index, plasma renin activity, and aldosterone concentration in all studied patients. A decrease of total catecholamine concentration appeared in patients treated with propranolol. Weaker effect of pindolol on the studied parameters may be connected with its intrinsic sympathicomimetic activity. A correlation was shown between the decrease of the left-ventricular myocardium mass, and the decrease of systolic arterial blood pressure.
研究了普萘洛尔和吲哚洛尔治疗8周对左心室心肌质量、左心室心肌质量指数、血浆肾素活性、血清醛固酮及总儿茶酚胺浓度的影响。研究对象为72例轻度原发性动脉高血压患者。结果显示，所有研究患者的左心室心肌质量、左心室心肌质量指数、血浆肾素活性及醛固酮浓度均有统计学意义的下降。普萘洛尔治疗的患者总儿茶酚胺浓度降低。吲哚洛尔对所研究参数的作用较弱可能与其内在拟交感活性有关。左心室心肌质量的降低与收缩期动脉血压的降低之间存在相关性。
