Kashimura M, Matsuura Y, Kawagoe T, Toki N, Sugihara K
Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Acta Cytol. 1993 Nov-Dec;37(6):871-5.
Cytologic findings on various vulvar squamous lesions are described in order to elucidate the usefulness of vulvar cytology. Lichen sclerosus, hyperplastic dystrophy and dysplasia with a few exfoliated anucleate squamous cells could not be differentiated cytologically. Numerous parakeratotic cells and dyskaryotic cells were identified in squamous cell carcinoma in situ. Three cytologic patterns were presented in cases of frankly invasive squamous cell carcinoma: negative cytology with parakeratotic cells, suspicious cytology with dyskaryotic cells and positive cytology with malignant cells. Verrucous carcinoma yielded only anucleate squamous cells. Parakeratotic cells without nuclear atypia seemed to be neoplastic cells on vulvar cytology.
描述了各种外阴鳞状病变的细胞学发现，以阐明外阴细胞学的实用性。细胞学上无法区分硬化性苔藓、增生性营养不良和伴有少量脱落无核鳞状细胞的发育异常。原位鳞状细胞癌中可识别出大量不全角化细胞和双核异型细胞。在浸润性鳞状细胞癌病例中呈现出三种细胞学模式：伴有不全角化细胞的阴性细胞学、伴有双核异型细胞的可疑细胞学和伴有恶性细胞的阳性细胞学。疣状癌仅产生无核鳞状细胞。在外阴细胞学中，无核异型性的不全角化细胞似乎是肿瘤细胞。
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