Haus O
Katedry i Zakładu Patofizjologii AM, Wrocławiu.
Acta Haematol Pol. 1993;24(3):221-5.
Ph-negative chronic myeloid leukemia [Ph(-)CML] is a heterogenous group of conditions characterized by similar cytogenetic pattern but variable changes at the molecular level. All cases with BCR gene rearrangement in this group have clinical and haematological course similar to Ph(+)CML. However, CML without rearrangements of ABL and BCR genes, called "atypical CML", forms a separate entity showing clinical and morphological features different from classical CML.
Ph阴性慢性髓性白血病[Ph(-)CML]是一组异质性疾病，其特征是细胞遗传学模式相似，但分子水平存在可变变化。该组中所有具有BCR基因重排的病例，其临床和血液学病程与Ph阳性CML相似。然而，没有ABL和BCR基因重排的CML，即“非典型CML”，构成了一个独立的实体，其临床和形态学特征与经典CML不同。
