Rex D K, Sledge G W, Harper P A, Ulbright T M, Loehrer P J, Helper D J, Smith J J, Wiersema M J, Hawes R H, Lehman G A
Department of Medicine, Indiana University School of Medicine, Indianapolis.
Am J Gastroenterol. 1993 Dec;88(12):2009-14.
One hundred ninety-three asymptomatic women with a personal history of breast cancer underwent screening colonoscopy. One hundred sixty-eight women had breast cancer as their only potential risk factor for colonic neoplasia, and 25 had a family history of colorectal neoplasia in addition to their personal history of breast cancer. Among women with breast cancer, increasing age and body weight were each predictive of an increasing prevalence of colonic adenomas. The prevalence of colonic adenomas in women aged 50-75 yr whose only potential risk factor was breast cancer was 18%, and was identical to the prevalence of colonic adenomas in 186 asymptomatic average-risk control women aged 50-75 yr (odds ratio 1.0, 95% CI 0.54-1.87). We conclude that a personal history of breast cancer does not predict a higher prevalence of colonic adenomas.
193名有乳腺癌个人病史的无症状女性接受了结肠镜筛查。168名女性的乳腺癌是其结肠肿瘤的唯一潜在风险因素，25名女性除了有乳腺癌个人病史外，还有结肠肿瘤家族史。在患有乳腺癌的女性中，年龄增长和体重增加均预示着结肠腺瘤患病率上升。仅以乳腺癌为唯一潜在风险因素的50 - 75岁女性中，结肠腺瘤患病率为18%，与186名50 - 75岁无症状平均风险对照女性的结肠腺瘤患病率相同（优势比1.0，95%可信区间0.54 - 1.87）。我们得出结论，乳腺癌个人病史并不能预测结肠腺瘤的更高患病率。
