Mandava S, Zulauf M, Zeyen T, Caprioli J
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut.
Am J Ophthalmol. 1993 Dec 15;116(6):684-91. doi: 10.1016/s0002-9394(14)73466-x.
We used a statistical cluster analysis to analyze patterns of loss in 76 visual fields with typical glaucomatous defects to identify natural groupings of test locations in the visual field. Eleven clusters in the Octopus Program G1 (Interzeag, Inc., Northboro, Massachusetts) visual field were thus defined. In a separate population of 70 early glaucomatous and 70 age-matched normal visual fields, the local mean defects within these clusters and the global mean defect were calculated to assess their relative abilities to discriminate between the two groups. The 11 clustered mean defects collectively had a sensitivity of 90% and a specificity of 93%; the global mean defect had a sensitivity of 81% and a specificity of 91%. Additionally, we examined the long-term fluctuation clusters of test locations compared to the long-term fluctuation of individual test locations. Four hundred ten visual fields of 93 clinically stable eyes of 67 patients with glaucoma, as well as 210 visual fields of 105 eyes of 105 normal subjects were studied. In the stable glaucoma group, mean fluctuation of clustered test locations was 3.5 dB2, and mean fluctuation of individual test locations was 7.0 dB2. In the normal group, the respective values were 0.6 dB2 and 1.8 dB2. Cluster analysis was effective in detecting localized loss and in dampening long-term fluctuation. We studied the use of clusters in distinguishing normal from glaucomatous as well as stable from deteriorating visual fields.
我们使用统计聚类分析来分析76个具有典型青光眼性缺损的视野中的缺损模式，以识别视野中测试位置的自然分组。由此在Octopus Program G1（Interzeag公司，马萨诸塞州诺斯伯勒）视野中定义了11个聚类。在一个由70个早期青光眼视野和70个年龄匹配的正常视野组成的独立人群中，计算这些聚类内的局部平均缺损和总体平均缺损，以评估它们区分两组的相对能力。11个聚类平均缺损的总体敏感度为90%，特异度为93%；总体平均缺损的敏感度为81%，特异度为91%。此外，我们将测试位置的长期波动聚类与单个测试位置的长期波动进行了比较。研究了67例青光眼患者93只临床稳定眼睛的410个视野，以及105名正常受试者105只眼睛的210个视野。在稳定青光眼组中，聚类测试位置的平均波动为3.5 dB2，单个测试位置的平均波动为7.0 dB2。在正常组中，相应的值分别为0.6 dB2和1.8 dB2。聚类分析在检测局部性缺损和抑制长期波动方面是有效的。我们研究了聚类在区分正常视野与青光眼视野以及稳定视野与恶化视野方面的应用。
