Yen B C, Kahn H, Schiller A L, Klein M J, Phelps R G, Lebwohl M G
Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029-6574.
Arch Pathol Lab Med. 1993 Dec;117(12):1252-4.
Multiple hamartoma syndrome, also known as Cowden's disease, is a rare genodermatosis with characteristic mucocutaneous lesions associated with multiple internal abnormalities. We describe a patient having classic dermatologic manifestations of Cowden's disease and multiple neoplasia including follicular adenocarcinoma of the thyroid gland with lung metastasis, intraductal breast carcinoma within a fibroadenoma, and an osteosarcoma. To our knowledge, this is the first reported case of an osteosarcoma in Cowden's disease.
多发性错构瘤综合征，也称为考登病，是一种罕见的遗传性皮肤病，具有特征性的黏膜皮肤病变，并伴有多种内脏异常。我们描述了一名患有考登病典型皮肤表现和多种肿瘤的患者，包括伴有肺转移的甲状腺滤泡腺癌、纤维腺瘤内的导管内乳腺癌以及骨肉瘤。据我们所知，这是考登病中首次报道的骨肉瘤病例。
