Kolb E, Boldt E, Eltohami M, Kirbach H, Ulbrich M, Wahren M
Veterinär-Physiologisch-Chemischen Institut, Universität Leipzig.
Berl Munch Tierarztl Wochenschr. 1993 Oct;106(10):341-7.
In normally fed lambs (group 1) the content of ascorbic acid (AA) in the plasma on day 8, 18, 28, 38, 48, 60 and 100 after birth was the same as in lambs, that were fed on days 8 to 17 (group 2), 8 to 26 (group 3) and 8 to 35 (group 4) on the maintenance level. The restrictive feeding induced for a certain time a decrease in the glucose content of the plasma. In the lambs of group 2 and 3 there was no differences in the content of AA in 14 tissues compared to group 1. In the lambs of group 4 the body weight on the 35th day was only 54 and the mass of the hypophysis 60, of the lung 55.9, of the liver 51, of the heart 47.2, of the spleen 44.7 and of the kidney 38% of that of group 1; there was a tendency to a lower content of AA in most tissues. With increasing age the content of AA in the cerebrum, in the cerebellum, in the brain stem and in the testicles decreased; the highest content in the hypophysis was determined on day 180. The regulation of the synthesis of AA in the liver under normal and pathological conditions is discussed.
在正常喂养的羔羊(第1组)中,出生后第8、18、28、38、48、60和100天血浆中抗坏血酸(AA)的含量与在维持水平下于第8至17天(第2组)、8至26天(第3组)和8至35天(第4组)喂养的羔羊相同。在一定时间内限制喂养会导致血浆葡萄糖含量降低。与第1组相比,第2组和第3组羔羊的14种组织中AA含量没有差异。第4组羔羊在第35天的体重仅为第1组的54%,垂体质量为60%,肺为55.9%,肝脏为51%,心脏为47.2%,脾脏为44.7%,肾脏为38%;大多数组织中AA含量有降低的趋势。随着年龄的增长,大脑、小脑、脑干和睾丸中AA的含量降低;垂体中AA含量在第180天最高。本文讨论了正常和病理条件下肝脏中AA合成的调节。