A biochemical marker for differentiation is present in an in vitro aging cell system.
作者信息
Rogakou E P, Sekeri-Pataryas K E
机构信息
Institute of Biology, N.R.C. Demokritos, Aghia Paraskevi, Attiki, Greece.
出版信息
Biochem Biophys Res Commun. 1993 Nov 15;196(3):1274-9. doi: 10.1006/bbrc.1993.2390.
PMID:8250883
Abstract
In this study it is shown that in an in vitro aging cell system of human diploid fibroblasts the ratio of the histone variants H2A.1/H2A.2 decreases in a linear manner as a function of cumulative population doublings This ratio is known to decrease during differentiation. This finding reinforces the theory that cellular aging is a result of differentiation and programmed cell death rather than degeneration.
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