Kitano K, Kobayashi H, Maeyama H, Miyabayashi H, Furuta S
Second Department of Internal Medicine, Shinshu University School of Medicine, Japan.
Br J Haematol. 1993 Sep;85(1):176-8. doi: 10.1111/j.1365-2141.1993.tb08663.x.
We present a patient with acute monoblastic leukaemia (AMoL) who achieved a complete remission on combination therapy with macrophage colony-stimulating factor (M-CSF) and low dose of cytosine arabinoside (ara-C). This 26-year-old man was admitted with a relapse of AMoL which proved refractory to several chemotherapeutic regimens. To kill dormant leukaemic cells, we administered 20 mg/m2 ara-C by continuous intravenous infusion and 800 x 10(4) unit M-CSF by 30 min drip intravenous infusion together for 14 d. The blasts disappeared, followed by a recovery of normal blood cells. The patient continued the complete remission for 5 months. This observation suggests that a combination M-CSF and a low dose of ara-C may be useful in treating some patients with AMoL.
我们报告了一名急性单核细胞白血病（AMoL）患者，该患者在接受巨噬细胞集落刺激因子（M-CSF）和低剂量阿糖胞苷（ara-C）联合治疗后实现了完全缓解。这名26岁男性因AMoL复发入院，此前多种化疗方案均对其无效。为了杀死休眠的白血病细胞，我们连续静脉输注20 mg/m²阿糖胞苷，并在30分钟内静脉滴注800×10⁴单位M-CSF，共持续14天。原始细胞消失，随后正常血细胞恢复。该患者持续完全缓解了5个月。这一观察结果表明，M-CSF与低剂量阿糖胞苷联合使用可能对治疗部分AMoL患者有用。
