阿尔茨海默病中的乙酰化酶多态性
Acetylator polymorphism in Alzheimer's disease.
作者信息
Ladero J M, Barquero M S, Coria F, Molina J A, Jiménez-Jiménez F J, Benítez J
机构信息
Service of Gastroenterology, Hospital Universitario de San Carlos, University Complutense (Department of Medicine), Madrid, Spain.
出版信息
Eur J Med. 1993 May;2(5):281-3.
OBJECTIVES
To elucidate whether any relationship exists between genetic acetylator polymorphism and the risk of developing Alzheimer's disease.
METHODS
Acetylator polymorphism has been determined, using sulphamethazine, in 54 patients with Alzheimer's disease or senile dementia of Alzheimer type and in 93 age-matched controls.
RESULTS
Thirty-one patients (57.4%) and 54 controls (58%) were classified as slow acetylators (non-significant difference). No relation was found between acetylator polymorphism and age at onset of disease and scores of Minimental examination and Blessed, Tomlinson & Roth scale in the group of patients with Alzheimer's disease/senile dementia of Alzheimer type.
CONCLUSIONS
Our results do not support the existence of any relationship between acetylator polymorphism and the risk of developing Alzheimer type dementia.
目的
阐明基因乙酰化多态性与患阿尔茨海默病风险之间是否存在任何关联。
方法
使用磺胺二甲嘧啶对54例阿尔茨海默病或阿尔茨海默型老年痴呆患者以及93例年龄匹配的对照者进行了乙酰化多态性测定。
结果
31例患者（57.4%）和54例对照者（58%）被归类为慢乙酰化者（无显著差异）。在阿尔茨海默病/阿尔茨海默型老年痴呆患者组中，未发现乙酰化多态性与发病年龄、简易精神状态检查得分以及Blessed、Tomlinson和Roth量表得分之间存在关联。
结论
我们的结果不支持乙酰化多态性与患阿尔茨海默型痴呆风险之间存在任何关联。
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