Schou M
Psychiatric Hospital, Risskov, Denmark.
Br J Psychiatry. 1993 Oct;163:514-8. doi: 10.1192/bjp.163.4.514.
The evidence for abstinence phenomena after discontinuation of lithium is weak and ambiguous. Early manic and depressive recurrences after lithium discontinuation may suggest rebound, but studies carried out with appropriate methodology have failed to confirm its reality. Discontinuation of prophylactic lithium treatment of recurrent manic-depressive illness, whether abrupt or gradual, involves risk of relapse, but the existence of a special lithium withdrawal syndrome remains unproven.
停用锂盐后出现戒断现象的证据薄弱且不明确。停用锂盐后早期出现的躁狂和抑郁复发可能提示反跳，但采用适当方法进行的研究未能证实其存在。对于复发性躁狂抑郁症，无论突然还是逐渐停用预防性锂盐治疗，都存在复发风险，但特殊的锂盐戒断综合征的存在仍未得到证实。
