Nagatani T, Miyazawa M, Matsuzaki T, Hayakawa H, Iemoto G, Kim S T, Baba N, Aihara M, Miyamoto H, Nakajima H
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Clin Exp Dermatol. 1993 Nov;18(6):530-6. doi: 10.1111/j.1365-2230.1993.tb01023.x.
Eleven cases of cutaneous B-cell lymphoma (CBCL) were studied. The ages at presentation ranged from 34 to 79 years (mean = 59.9 years). Six patients were female and five male. Five of the 11 patients had a solitary tumour and the other six had multiple tumours at initial presentation. According to Burg's classification, six cases were at stage I, two stage II, two stage III and one was at stage IV at initial presentation. Abnormalities in laboratory data were rare, except for serum lactic dehydrogenase values. Epidermotropism was not detected, and the area mainly affected by neoplastic cells was the reticular dermis (seven cases) and subcutis (four cases). Biopsy specimens from the patients analysed by immunohistochemical techniques on paraffin or cryostat sections showed CD20 and/or CD22 positivity. Biopsy specimens from two patients which showed CD10 positivity were diffuse large cell types by the working formulation and presented as pre-B-cell lymphoma. At least two groups of CBCL were demonstrable on the basis of prognosis. One was a benign low-grade lymphoma presenting with solitary tumours, mature B-cell markers and intermediate-grade pathology, and the other was a high-grade lymphoma with multiple tumours, pre-B-cell or mature B-cell markers and a poor prognosis.
对11例皮肤B细胞淋巴瘤（CBCL）进行了研究。就诊时年龄范围为34至79岁（平均 = 59.9岁）。6例为女性，5例为男性。11例患者中，5例初诊时为单发肿瘤，另外6例为多发肿瘤。根据伯格分类法，初诊时6例处于I期，2例处于II期，2例处于III期，1例处于IV期。除血清乳酸脱氢酶值外，实验室数据异常情况罕见。未检测到亲表皮现象，肿瘤细胞主要累及的部位是网状真皮（7例）和皮下组织（4例）。通过对石蜡切片或低温恒温器切片进行免疫组织化学技术分析，患者的活检标本显示CD20和/或CD22呈阳性。2例活检标本显示CD10呈阳性，根据工作分类法为弥漫大细胞型，表现为前B细胞淋巴瘤。基于预后至少可区分出两组CBCL。一组是良性低度淋巴瘤，表现为单发肿瘤、成熟B细胞标志物和中度病理特征；另一组是高度淋巴瘤，有多发肿瘤、前B细胞或成熟B细胞标志物且预后较差。
