不同血管扩张剂对大鼠门静脉和肠系膜动脉作用的比较。

Comparison of the effects of various vasodilators on the rat portal vein and mesenteric artery.

作者信息

Suga T, Itoh H, Shimomura A, Kusagawa M, Ito M, Takase K, Konishi T, Nakano T

机构信息

First Department of Internal Medicine, Faculty of Medicine, University of Mie, Japan.

出版信息

Eur J Pharmacol. 1993 Sep 28;242(2):129-36. doi: 10.1016/0014-2999(93)90072-p.

DOI:10.1016/0014-2999(93)90072-p

PMID:8253109

Abstract

The effects of various vasodilators on isolated helical strips of rat portal vein and mesenteric artery were examined. Dilazep, ibudilast, nifedipine, verapamil and papaverine relaxed the KCl- and norepinephrine-induced contractions of the portal vein to a greater extent than they relaxed those of mesenteric artery. Dibutyryl cyclic AMP and NKH477 did not show any significant difference in terms of the concentrations that produced 50% inhibition (IC50) of the KCl-induced contraction of the portal vein and mesenteric artery. The relaxant effects of nitroprusside and isosorbide dinitrate on the KCl- and norepinephrine-induced contractions of the portal vein were less potent than their effects on contractions of the mesenteric artery. The agents that inhibited the contractions of the portal vein more potently than those of the mesenteric artery were associated with parallel shifts to the right of the concentration-response curves for CaCl2 in both preparations. These results suggest that drugs with a Ca2+ channel blocking action may be preferable to those that cause a decrease in portal pressure for treatment of portal hypertension.

摘要

研究了各种血管扩张剂对大鼠门静脉和肠系膜动脉离体螺旋条的作用。地拉卓、异丁司特、硝苯地平、维拉帕米和罂粟碱对氯化钾和去甲肾上腺素诱导的门静脉收缩的松弛作用，比对肠系膜动脉收缩的松弛作用更强。二丁酰环磷腺苷和NKH477在产生50%抑制氯化钾诱导的门静脉和肠系膜动脉收缩的浓度（IC50）方面没有显示出任何显著差异。硝普钠和硝酸异山梨酯对氯化钾和去甲肾上腺素诱导的门静脉收缩的松弛作用，比对肠系膜动脉收缩的作用弱。比肠系膜动脉收缩更有效地抑制门静脉收缩的药物，与两种制剂中氯化钙浓度-反应曲线平行右移有关。这些结果表明，对于门静脉高压的治疗，具有钙通道阻滞作用的药物可能比那些导致门静脉压力降低的药物更可取。