一氧化氮调节大鼠交感神经元中的钙离子通道电流。

Nitric oxide modulates Ca2+ channel currents in rat sympathetic neurons.

作者信息

Chen C, Schofield G G

机构信息

Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112.

出版信息

Eur J Pharmacol. 1993 Oct 12;243(1):83-6. doi: 10.1016/0014-2999(93)90171-d.

DOI:10.1016/0014-2999(93)90171-d

PMID:8253128

Abstract

The effects of nitric oxide on the Ca2+ channel currents of adult rat superior cervical ganglion neurons were investigated using the whole-cell patch-clamp technique. Nitric oxide-containing compounds sodium nitroprusside and S-nitroso-N-acetyl-penicillamine increased the amplitude of Ca2+ currents by intracellular application. In addition, both sodium nitroprusside and S-nitroso-N-acetylpenicillamine reduced norepinephrine-induced inhibition of Ca2+ currents. The results suggest that nitric oxide might be involved in the modulation of Ca(2+)-dependent neurotransmission in sympathetic neurons.

摘要

采用全细胞膜片钳技术研究了一氧化氮对成年大鼠颈上神经节神经元Ca2+通道电流的影响。通过细胞内给药，含一氧化氮的化合物硝普钠和S-亚硝基-N-乙酰青霉胺增加了Ca2+电流的幅度。此外，硝普钠和S-亚硝基-N-乙酰青霉胺均减弱了去甲肾上腺素对Ca2+电流的抑制作用。结果表明，一氧化氮可能参与了交感神经元中Ca(2+)依赖性神经传递的调节。