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大鼠眼外肌中肌球蛋白重链同工型模式的电泳分析。

Electrophoretic analysis of myosin heavy chain isoform patterns in extraocular muscles of the rat.

作者信息

Asmussen G, Traub I, Pette D

机构信息

Fakultät für Biologie, Universität Konstanz, Germany.

出版信息

FEBS Lett. 1993 Dec 6;335(2):243-5. doi: 10.1016/0014-5793(93)80738-g.

DOI:10.1016/0014-5793(93)80738-g
PMID:8253205
Abstract

Six oculorotatory muscles and the levator palpebrae muscle of the rat were analysed by SDS-PAGE for their myosin heavy chain (MHC) isoform patterns. Oculorotatory muscles display a marked predominance of fast MHC isoforms. They contain, in addition to the slow (MHCI) and fast (MHCIIb, MHCIId, MHCIIa) skeletal MHCs, the neonatal MHCneo and the extraocular MHCeom. The levator palpebrae, generally assumed to be a member of the extraocular muscle group because of its innervation by the oculomotor nerve, does not contain MHCneo and MHCeom. It resembles a fast-twitch skeletal muscle with a predominance of MHCIId.

摘要

通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)分析了大鼠的六条眼球旋转肌和提上睑肌的肌球蛋白重链(MHC)同工型模式。眼球旋转肌表现出快速MHC同工型的显著优势。除了慢肌(MHCI)和快肌(MHCIIb、MHCIId、MHCIIa)的骨骼肌MHC外,它们还含有新生MHCneo和眼外肌MHCeom。提上睑肌通常因其受动眼神经支配而被认为是眼外肌组的一员,但它不含有MHCneo和MHCeom。它类似于以MHCIId为主的快肌骨骼肌。

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