Claridge K G
Department of Clinical Pharmacology, St. Thomas' Hospital, London, UK.
Eye (Lond). 1993;7 ( Pt 4):507-10. doi: 10.1038/eye.1993.110.
Ocular blood flow is considered an important factor in determining the extent of visual damage occurring in primary open angle glaucoma (POAG). The effect of topical pilocarpine, a parasympathomimetic vasodilator, on the pulsatile ocular blood flow (POBF) in POAG subjects was studied. A pneumotonometer linked to the Langham Ocular Blood Flow System recorded the intraocular pressure (IOP) pulse from which POBF was calculated. Measurements were taken from 18 POAG subjects treated with both G pilocarpine and G timolol, 2 weeks after withdrawing G pilocarpine and again 1 week after reinstituting full treatment. Recordings from 20 POAG patients treated with only G timolol were taken as control values. There was no significant difference in the IOP or POBF between the controls and POAG patients on dual therapy. Furthermore when G pilocarpine was temporarily withdrawn there was no significant change in POBF despite a significant rise in IOP. The results imply that aqueous pilocarpine has no direct effect on the pulsatile component of ocular blood.
眼血流量被认为是决定原发性开角型青光眼（POAG）视觉损害程度的一个重要因素。研究了拟副交感神经血管扩张剂毛果芸香碱局部用药对POAG患者搏动性眼血流量（POBF）的影响。与兰厄姆眼血流系统相连的眼压计记录眼内压（IOP）脉搏，据此计算POBF。对18例接受毛果芸香碱和噻吗洛尔治疗的POAG患者进行测量，在停用毛果芸香碱2周后以及重新进行全剂量治疗1周后再次测量。将20例仅接受噻吗洛尔治疗的POAG患者的记录作为对照值。在联合治疗的对照组和POAG患者之间，IOP或POBF没有显著差异。此外，当暂时停用毛果芸香碱时，尽管IOP显著升高，但POBF没有显著变化。结果表明，毛果芸香碱滴眼液对眼血的搏动成分没有直接影响。
