Ferré S, O'Connor W T, Fuxe K, Ungerstedt U
Department of Neurochemistry, C.S.I.C., Barcelona, Spain.
J Neurosci. 1993 Dec;13(12):5402-6. doi: 10.1523/JNEUROSCI.13-12-05402.1993.
Recent pharmacological data suggest that a receptor-receptor interaction between adenosine A2 and dopamine D2 receptors in the brain underlies the behavioral effects of adenosine agonists and adenosine antagonists, such as caffeine and theophylline. According to this interaction, stimulation of A2 receptors inhibits and their blockade potentiates the effects of D2 receptor stimulation. Furthermore, both A2 and D2 receptors are selectively colocalized on GABAergic striopallidal neurons. In this microdialysis investigation the effect of intrastriatal infusion of adenosine and dopamine agonists and antagonists alone or in combination was studied on the release of GABA from the terminals of the striopallidal neuron in awake, freely moving rats. We report that the GABAergic striopallidal neuron, which is a key component of the indirect striatal efferent pathway, is a main locus for A2-D2 interactions in the brain and possibly a main target for the central actions of adenosine agonists and antagonists.
近期药理学数据表明，大脑中腺苷A2受体与多巴胺D2受体之间的受体 - 受体相互作用是腺苷激动剂和腺苷拮抗剂（如咖啡因和茶碱）行为效应的基础。根据这种相互作用，刺激A2受体可产生抑制作用，而阻断A2受体则会增强D2受体刺激的效应。此外，A2和D2受体均选择性地共同定位于γ-氨基丁酸（GABA）能纹状体苍白球神经元上。在这项微透析研究中，单独或联合向清醒、自由活动的大鼠纹状体内注射腺苷、多巴胺激动剂和拮抗剂，研究其对纹状体苍白球神经元终末释放GABA的影响。我们报告称，作为纹状体间接传出通路的关键组成部分，GABA能纹状体苍白球神经元是大脑中A2 - D2相互作用的主要位点，可能也是腺苷激动剂和拮抗剂中枢作用的主要靶点。
