Di Franco M J, Marlink R, Hunter D J, Tosteson T, Mayer K, Essex M
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115.
J Acquir Immune Defic Syndr (1988). 1993 Dec;6(12):1297-300.
This study evaluated the effect of continued heroin use during methadone treatment on serum neopterin levels in 40 human immunodeficiency virus (HIV) type 1 seropositive (HIV+) and 70 seronegative (HIV-) intravenous drug users (IVDUs). Persistent drug use, determined by urinary evidence of opiates, was more common in HIV+ than in HIV- IVDUs (p = 0.01). Serum neopterin concentration, an indicator of increased probability of progression to AIDS, was elevated in HIV+ IVDUs, p < 0.0001 (mean 16.0 nmol/L) compared to that of HIV- IVDUs (mean 10.0 nmol/L) and in persistent IV drug users compared with abstainers, p < 0.0001. The effect of drug use and HIV status on serum neopterin was not explained by differences in methadone treatment, age, sex, or total years of i.v. drug use. Neopterin decreased in 25 IVDUs, regardless of HIV serostatus, treated with methadone for an average of 1.5 years.
本研究评估了40名1型人类免疫缺陷病毒（HIV）血清阳性（HIV+）和70名血清阴性（HIV-）的静脉吸毒者（IVDUs）在美沙酮治疗期间持续使用海洛因对血清新蝶呤水平的影响。通过尿液中阿片类物质的证据确定的持续吸毒在HIV+的IVDUs中比在HIV-的IVDUs中更常见（p = 0.01）。血清新蝶呤浓度是进展为艾滋病可能性增加的一个指标，与HIV-的IVDUs（平均10.0 nmol/L）相比，HIV+的IVDUs中该浓度升高，p < 0.0001（平均16.0 nmol/L），并且在持续静脉吸毒者中与戒毒者相比，p < 0.0001。吸毒和HIV状态对血清新蝶呤的影响不能用美沙酮治疗、年龄、性别或静脉吸毒总年限的差异来解释。25名IVDUs（无论HIV血清状态如何）接受美沙酮治疗平均1.5年后，新蝶呤水平下降。
