Serpell M G, DeLeo J A, Coombs D W, Colburn R W, Twitchell B B, Willenbring S, Fromm C
Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, N.H. 03756.
Life Sci. 1993;53(25):1887-92. doi: 10.1016/0024-3205(93)90028-2.
There is substantial evidence that sciatic cryoneurolysis (SCN, freeze lesion of the sciatic nerve) is a neuropathic pain model in the rat. During characterization of this model, SCN was performed 4 days after either a sham operation or the insertion of an indwelling intrathecal catheter preparatory to selective spinal drug administration. Body weight and autotomy scores were recorded for the next 22 days until sacrifice. The catheter group experienced significant weight loss (7.5%) by 4 days but rapidly regained to parity with the sham group. Autotomy scores and the frequency of severe autotomy (score > 3) were less at day 22 in the catheter group as compared with the sham-control group (p < 0.005, p < 0.03, respectively). Intrathecal catheterization itself effects the degree of behavioral response to neurogenic pain and thus, should be controlled for in studies using nociceptive animal models.
有大量证据表明，坐骨神经冷冻神经溶解术（SCN，即坐骨神经冷冻损伤）是大鼠的一种神经性疼痛模型。在对该模型进行特征描述期间，在假手术或插入用于选择性脊髓给药的留置鞘内导管4天后进行SCN。在接下来的22天直至处死期间记录体重和自残评分。导管组在4天时体重显著下降（7.5%），但迅速恢复至与假手术组相当。与假手术对照组相比，导管组在第22天时的自残评分和严重自残频率（评分>3）较低（分别为p<0.005，p<0.03）。鞘内导管插入本身会影响对神经性疼痛的行为反应程度，因此，在使用伤害性动物模型的研究中应加以控制。
