Azukizawa M, Murata Y, Ikenoue T, Martin C B, Hershman J M
J Clin Endocrinol Metab. 1976 Nov;43(5):1020-8. doi: 10.1210/jcem-43-5-1020.
The effect of thyrotropin-releasing hormone (TRH) on the pituitary-thyroid axis and on prolactin secretion was studied in pregnant Rhesus monkeys during the latter period of gestation and in non-pregnant female controls. The baseline plasma concentrations of TSH, T3, T4, and prolactin (PRL) of pregnant monkeys did not differ from those of non-pregnant monkeys. After administration of TRH, plasma prolactin rose to higher levels in pregnant monkeys than in non-pregnant monkeys whereas there was a similar response of plasma TSH, T4 and T3 in both groups. The baseline plasma TSH was elevated and plasma T3 was decreased in the fetus compared with the mother. Administration of TRH iv to the maternal monkey caused a larger response in the fetal plasma TSH than in that of the mother and was followed by larger increments in plasma T4 and T3 concentrations in the fetuses than in the mothers. The larger increments of plasma TSH and thyroid hormones in the fetus compared with the mother also occurred when TRH was given iv to the fetus. There was a significant rise of plasma prolactin in both mother and fetus after administration of TRH to mother or fetus; the increase of plasma PRL was much higher in the mother than in the fetus. The data show that TRH can cross the primate placenta in either the maternal to fetal or fetal to maternal direction. The fetal thyroid of the Rhesus monkey during the latter period of gestation can release both T4 and T3 in response to TSH.
在妊娠后期的怀孕恒河猴和未怀孕的雌性对照猴中，研究了促甲状腺激素释放激素（TRH）对垂体-甲状腺轴及催乳素分泌的影响。怀孕猴子的促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）和催乳素（PRL）的基线血浆浓度与未怀孕猴子的无差异。给予TRH后，怀孕猴子血浆催乳素升高至比未怀孕猴子更高的水平，而两组血浆TSH、T4和T3的反应相似。与母体相比，胎儿的基线血浆TSH升高而血浆T3降低。对母猴静脉注射TRH后，胎儿血浆TSH的反应大于母体，随后胎儿血浆T4和T3浓度的升高幅度也大于母体。当对胎儿静脉注射TRH时，与母体相比，胎儿血浆TSH和甲状腺激素的升高幅度也更大。对母体或胎儿给予TRH后，母体和胎儿的血浆催乳素均显著升高；母体血浆PRL的升高幅度远高于胎儿。数据表明，TRH可在母体到胎儿或胎儿到母体的方向穿过灵长类动物胎盘。妊娠后期恒河猴胎儿的甲状腺可响应TSH释放T4和T3。
