Spinhoven P, Onstein E J, Sterk P J
Rijksuniversiteit Leiden, Vakgroep Psychiatrie, Oegstgeest.
Ned Tijdschr Geneeskd. 1993 Nov 6;137(45):2315-8.
To investigate the importance of hyperventilation in the pathogenesis of panic attacks.
Descriptive.
The Jelgersma Outpatient Clinic at Oegstgeest and the University Hospital Leiden, the Netherlands.
In 57 psychiatric patients with a panic disorder and 96 somatic patients with unexplained somatic complaints suggestive of hyperventilation, a Hyperventilation Provocation Test (HVPT) was conducted. Of the somatic patients, 33 had recently experienced a panic attack. During the test, various physiological and symptom criteria for the Hyperventilation Syndrome were assessed. Several measures for concomitant psychopathology were collected as well.
No significant differences were found in physiological criteria for the Hyperventilation Syndrome between psychiatric patients with a panic disorder (PD) and somatic patients with (PA+) or without (PA-) a recent panic attack. On all symptom criteria, however, PD and PA+ patients obtained comparable scores, while both groups scored higher than PA- patients. On most measures for concomitant psychopathology, PD patients scored higher than PA+ patients, who on their part scored higher than PA- patients.
Hyperventilation is of secondary importance in the pathogenesis of panic attacks and an early diagnosis of panic attacks or panic disorder may be conducive to more adequate treatment.
探讨过度换气在惊恐发作发病机制中的重要性。
描述性研究。
荷兰奥赫斯特盖斯特的耶尔格斯马门诊诊所和莱顿大学医学中心。
对57例惊恐障碍精神病患者和96例有提示过度换气的不明原因躯体主诉的躯体疾病患者进行过度换气激发试验（HVPT）。在躯体疾病患者中，33例最近经历过惊恐发作。在试验过程中，评估了过度换气综合征的各种生理和症状标准。还收集了一些伴随精神病理学的测量数据。
患有惊恐障碍（PD）的精神病患者与近期有（PA+）或无（PA-）惊恐发作的躯体疾病患者在过度换气综合征的生理标准上未发现显著差异。然而，在所有症状标准上，PD患者和PA+患者得分相当，而这两组得分均高于PA-患者。在大多数伴随精神病理学的测量指标上，PD患者得分高于PA+患者，而PA+患者得分又高于PA-患者。
过度换气在惊恐发作的发病机制中起次要作用，惊恐发作或惊恐障碍的早期诊断可能有助于更充分的治疗。
