Johns D R, Stein A G, Wityk R
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Neurology. 1993 Dec;43(12):2471-3. doi: 10.1212/wnl.43.12.2471.
Herpes simplex encephalitis (HSE) is commonly treated empirically with acyclovir without confirmatory brain biopsy. Three consecutive adults with molecularly verified mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presented with, and were treated for, apparent HSE. MELAS syndrome in adults may present as an atypical, recurrent form of HSE and should be added to the list of neurologic diseases that can mimic HSE.
单纯疱疹病毒性脑炎（HSE）通常在未经脑活检确诊的情况下经验性使用阿昔洛韦进行治疗。三名连续出现分子学确诊的线粒体脑肌病、乳酸酸中毒和卒中样发作（MELAS）综合征的成年人表现为疑似HSE并接受了治疗。成人MELAS综合征可能表现为HSE的非典型复发性形式，应列入可模仿HSE的神经系统疾病清单。
