Cohen M D, Auringer S T, Grosfeld J L, Galliani C A, Heerema N A
Department of Radiology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46202-5200.
Pediatr Radiol. 1993;23(6):463-6. doi: 10.1007/BF02012454.
The purpose of this study is to present three patients with multifocal primary neuroblastoma, to review the literature, and describe the radiographic findings.
Three children with multifocal neuroblastoma have been identified. The case histories and imaging findings in these patients are reviewed.
Two children had synchronous and one child had metachronous multifocal primary neuroblastoma. The primary tumors were both in the abdomen in one patient, both in the chest in another patient, and in the chest and abdomen in the third patient. Evidence for multifocal origin of these tumors, rather than metastatic spread, is presented.
Multifocal primary neuroblastomas can occur. The tumors maybe synchronous or metachronous. Awareness of this disorder may prevent errors in diagnosis and staging. Although not identified in our patients there is a strong familial incidence of neuroblastomas in those patients with multifocal tumors.
本研究的目的是介绍三例多灶性原发性神经母细胞瘤患者，回顾相关文献并描述影像学表现。
已确定三名多灶性神经母细胞瘤患儿。回顾了这些患者的病史和影像学检查结果。
两名患儿为同时性多灶性原发性神经母细胞瘤，一名患儿为异时性多灶性原发性神经母细胞瘤。一名患者的原发性肿瘤均位于腹部，另一名患者的均位于胸部，第三名患者的则位于胸部和腹部。文中提供了这些肿瘤多灶起源而非转移扩散的证据。
多灶性原发性神经母细胞瘤可能会发生。肿瘤可能是同时性或异时性的。认识这种疾病可能会避免诊断和分期错误。尽管在我们的患者中未发现，但多灶性肿瘤患者的神经母细胞瘤有很强的家族发病率。
