烟酰胺与混合气体：对EMT6和HRT18肿瘤放射敏感性的主要影响。

Nicotinamide and carbogen: major effect on the radiosensitivity of EMT6 and HRT18 tumours.

作者信息

Simon J M, Lartigau E, Guichard M

机构信息

Laboratoire de Radiobiologie Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France.

出版信息

Radiother Oncol. 1993 Sep;28(3):203-7. doi: 10.1016/0167-8140(93)90059-h.

DOI:10.1016/0167-8140(93)90059-h

PMID:8255997

Abstract

The effect of nicotinamide and/or carbogen breathing on the response of EMT6 and HRT18 tumours, irradiated in vivo, was evaluated using an in vitro colony assay. In the single dose schedules, the most efficient treatment was carbogen plus nicotinamide compared to air breathing mice. In a fractionated regime carbogen plus nicotinamide increased also response to radiation.

摘要

使用体外集落测定法评估烟酰胺和/或卡波金呼吸对体内照射的EMT6和HRT18肿瘤反应的影响。在单次剂量方案中，与呼吸空气的小鼠相比，最有效的治疗方法是卡波金加烟酰胺。在分次照射方案中，卡波金加烟酰胺也增加了对辐射的反应。