Sumitomo N, Ushinohama H, Hara M, Otuka M, Harada K, Okuni M
Department of Pediatrics, Nihon University School of Medicine.
Kokyu To Junkan. 1993 Nov;41(11):1079-82.
Nine children with arrhythmia (1 automatic atrial tachycardia, 1 premature ventricular construction, and 7 ventricular tachycardia) who started oral treatment using flecainide were studied. All but 2 cases (1 post operative ventricular septal defect, 1 post operative tetralogy of Fallot) had ostensibly normal heart on physical examination, chest X ray and echocardiogram. To raise serum level above 200ng/ml, flecainide dose over 80mg/m2 or 3mg/kg was needed. There was negative correlation between dose (y: mg/kg) and age (x: year) (y = 5.2-0.16x, r = 0.88) in this group. No serious side effect indicating the need to discontinue further medication was detected. In electrocardiogram, PR, QRS and QT interval was not changed before or after the medication. Premature ventricular contraction disappeared in 2 of 8 cases (25%), decreased in number in 3 (38%), did not change in 1 (13%) and increased in number in 2 (25%). However ventricular tachycardia rate decreased or disappeared in all of the 5 cases whose ventricular tachycardia was detected in Holter electrocardiogram. Flecainide seems more effective for sustained ventricular tachycardia than for nonsustained ventricular tachycardia.
对9例开始口服氟卡尼治疗的心律失常患儿（1例自动性房性心动过速、1例室性早搏和7例室性心动过速）进行了研究。除2例（1例室间隔缺损术后、1例法洛四联症术后）外，所有患儿经体格检查、胸部X线和超声心动图检查，心脏表面上均正常。为使血清水平高于200ng/ml，需要氟卡尼剂量超过80mg/m²或3mg/kg。该组中剂量（y：mg/kg）与年龄（x：岁）之间呈负相关（y = 5.2 - 0.16x，r = 0.88）。未检测到表明需要停止进一步用药的严重副作用。在心电图方面，用药前后PR、QRS和QT间期未发生变化。8例室性早搏患儿中，2例（25%）早搏消失，3例（38%）早搏数量减少，1例（13%）未变化，2例（25%）早搏数量增加。然而，在动态心电图检测到室性心动过速的5例患儿中，所有患儿的室性心动过速频率均降低或消失。氟卡尼对持续性室性心动过速似乎比对非持续性室性心动过速更有效。
