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Cooperative binding by mouse IgG3 antibodies: implications for functional affinity, effector function, and isotype restriction.

作者信息

Greenspan N S, Cooper L J

机构信息

Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106.

出版信息

Springer Semin Immunopathol. 1993;15(2-3):275-91. doi: 10.1007/BF00201107.

DOI:10.1007/BF00201107
PMID:8256202
Abstract
摘要

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Cooperative binding by mouse IgG3 antibodies: implications for functional affinity, effector function, and isotype restriction.小鼠IgG3抗体的协同结合:对功能亲和力、效应器功能和同种型限制的影响
Springer Semin Immunopathol. 1993;15(2-3):275-91. doi: 10.1007/BF00201107.
2
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Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies?免疫球蛋白C(H)1恒定区结构域能否调节抗体的抗原结合亲和力?
J Clin Invest. 1996 Nov 15;98(10):2235-43. doi: 10.1172/JCI119033.
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Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2345-9. doi: 10.1073/pnas.90.6.2345.
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Clin Diagn Lab Immunol. 2005 Mar;12(3):380-6. doi: 10.1128/CDLI.12.3.380-386.2005.

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本文引用的文献

1
Variation in the group-specific carbohydrate of group A streptococci. I. Immunochemical studies on the carbohydrates of variant strains.A 群链球菌群特异性碳水化合物的变异。I. 变异菌株碳水化合物的免疫化学研究。
J Exp Med. 1955 Jul 1;102(1):11-28. doi: 10.1084/jem.102.1.11.
2
Variable region-identical monoclonal antibodies of different IgG subclass directed to Pseudomonas aeruginosa lipopolysaccharide O-specific side chain function differently.针对铜绿假单胞菌脂多糖O特异性侧链的不同IgG亚类的可变区相同的单克隆抗体功能各异。
J Infect Dis. 1993 Jan;167(1):221-6. doi: 10.1093/infdis/167.1.221.
3
Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains.
阿扎替利单抗在健康受试者以及实体瘤或慢性移植物抗宿主病患者中的半机制性群体药代动力学/药效学建模
Clin Pharmacol Ther. 2025 Mar;117(3):704-715. doi: 10.1002/cpt.3503. Epub 2024 Dec 20.
4
Picomolar-Level Sensing of Cannabidiol by Metal Nanoparticles Functionalized with Chemically Induced Dimerization Binders.基于化学诱导二聚化配体功能化金属纳米粒子对大麻二酚的皮摩尔级检测。
ACS Sens. 2023 Dec 22;8(12):4696-4706. doi: 10.1021/acssensors.3c01758. Epub 2023 Dec 11.
5
Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer's disease brain extracts.Aβ42 寡聚体特异性抗体 ALZ-201 降低阿尔茨海默病脑提取物的神经毒性。
Alzheimers Res Ther. 2022 Dec 29;14(1):196. doi: 10.1186/s13195-022-01141-1.
6
Synthetic nanobody-functionalized nanoparticles for accelerated development of rapid, accessible detection of viral antigens.合成纳米抗体功能化纳米颗粒用于加速开发快速、易于检测病毒抗原的方法。
Biosens Bioelectron. 2022 Apr 15;202:113971. doi: 10.1016/j.bios.2022.113971. Epub 2022 Jan 6.
7
Engineering the Human Fc Region Enables Direct Cell Killing by Cancer Glycan-Targeting Antibodies without the Need for Immune Effector Cells or Complement.工程化的人 Fc 区使癌症糖基靶向抗体能够直接杀伤细胞,而不需要免疫效应细胞或补体。
Cancer Res. 2020 Aug 15;80(16):3399-3412. doi: 10.1158/0008-5472.CAN-19-3599. Epub 2020 Jun 12.
8
CH2 Domain of Mouse IgG3 Governs Antibody Oligomerization, Increases Functional Affinity to Multivalent Antigens and Enhances Hemagglutination.CH2 结构域的小鼠 IgG3 控制抗体寡聚化,增加对多价抗原的功能亲和力,并增强血凝作用。
Front Immunol. 2018 May 23;9:1096. doi: 10.3389/fimmu.2018.01096. eCollection 2018.
9
Novel, Broadly Reactive Anticapsular Antibodies against Carbapenem-Resistant Klebsiella pneumoniae Protect from Infection.新型广谱抗碳青霉烯类耐药肺炎克雷伯菌荚膜抗体可预防感染。
mBio. 2018 Apr 3;9(2):e00091-18. doi: 10.1128/mBio.00091-18.
10
IgG cooperativity - Is there allostery? Implications for antibody functions and therapeutic antibody development.IgG 协同性——存在别构效应吗?对抗体功能和治疗性抗体开发的影响。
MAbs. 2017 Nov/Dec;9(8):1231-1252. doi: 10.1080/19420862.2017.1367074. Epub 2017 Aug 16.
重链恒定区在抗体-抗原相互作用中的作用。表达相同可变区的链球菌IgG抗体之间明显的特异性差异。
J Immunol. 1993 Mar 15;150(6):2231-42.
4
Mixing two monoclonal antibodies yields enhanced affinity for antigen.混合两种单克隆抗体可增强对抗原的亲和力。
J Immunol. 1982 Jun;128(6):2709-13.
5
Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type 1 and type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency.小鼠抗体的亚类限制。II. 正常小鼠和表达X连锁免疫缺陷的小鼠对1型和2型非胸腺依赖性抗原的IgG斑块形成细胞反应。
J Exp Med. 1980 Apr 1;151(4):853-62. doi: 10.1084/jem.151.4.853.
6
Polymorphism of heavy chain immunoglobulin isotypes in the Mus subgenus. I. Limited gamma 3 polymorphism revealed by antibodies raised in SPE wild-derived inbred strain.小家鼠亚属重链免疫球蛋白同种型的多态性。I. 由SPE野生来源近交系产生的抗体揭示的有限γ3多态性。
Immunogenetics. 1984;20(5):577-81. doi: 10.1007/BF00364359.
7
Isotype-specific T cell regulation of immunoglobulin expression.免疫球蛋白表达的同型特异性T细胞调节。
Immunol Rev. 1982;67:33-58. doi: 10.1111/j.1600-065x.1982.tb01054.x.
8
Detection of immunoglobulin heavy chain IgG3 polymorphism in wild mice with xenogeneic monoclonal antibodies.用异种单克隆抗体检测野生小鼠免疫球蛋白重链IgG3多态性
Immunogenetics. 1984;20(5):565-75. doi: 10.1007/BF00364358.
9
Antibody-induced conformational changes result in enhanced avidity of antibodies to different antigenic sites on the tick-borne encephalitis virus glycoprotein.抗体诱导的构象变化导致抗体对蜱传脑炎病毒糖蛋白上不同抗原位点的亲和力增强。
Virology. 1984 Feb;133(1):25-34. doi: 10.1016/0042-6822(84)90422-7.
10
Quantitative explanation for increased affinity shown by mixtures of monoclonal antibodies: importance of a circular complex.单克隆抗体混合物所表现出的亲和力增加的定量解释:环状复合物的重要性。
Mol Immunol. 1983 Apr;20(4):439-52. doi: 10.1016/0161-5890(83)90025-1.