Handberg J, Priø T K, Rohde K, Antonsen A, Hansen M
Medicinsk afdeling F, Hillerød Sygehus.
Ugeskr Laeger. 1993 Oct 25;155(43):3452-5.
A review of 158 cases of bacterial meningitis and meningococcal sepsis in adults is presented. The patients were admitted during a 11-year period, from 1980-1990. The incidence was 5.5/100,000 adults per year, which is high. The area had epidemics of meningococcal disease in the years 1987 and 1989. The bacterial agent was meningococci in 40.5%, pneumococci in 21.5% and unknown in 27.2%. The overall lethality was 13.9%, highest (26%) in patients who were infected by pneumococci. The meningococcal relative lethality was 14%. In the period of high meningococcal incidence 1986-1989, we found a relative lethality of 17%. The overall local hospital lethality was 18.3%, which has to be compared with 11.2% among patients primarily admitted to the County hospital. The lethality among patients who underwent emergency transfer from one of the local hospitals to the County hospital was 20%, which is as high as in the group of patients treated locally. Neither of these trends lethality are statistically significant at the level of 5%, tested by chi square tests.
本文对158例成人细菌性脑膜炎和脑膜炎球菌败血症病例进行了回顾。这些患者在1980年至1990年的11年期间入院。发病率为每年5.5/10万成人，这一发病率较高。该地区在1987年和1989年发生了脑膜炎球菌病流行。细菌病原体为脑膜炎球菌的占40.5%，肺炎球菌的占21.5%，不明的占27.2%。总体死亡率为13.9%，肺炎球菌感染患者的死亡率最高（26%）。脑膜炎球菌的相对死亡率为14%。在1986 - 1989年脑膜炎球菌发病率较高的时期，我们发现相对死亡率为17%。当地医院的总体死亡率为18.3%，这必须与主要入住县医院的患者中的11.2%进行比较。从当地医院之一紧急转至县医院的患者死亡率为20%，与在当地接受治疗的患者组一样高。通过卡方检验，这些死亡率趋势在5%的水平上均无统计学意义。
