Farmer D G, Shaked A, Colonna J O, Olthoff K M, Jurim O, Colquhoun S, Millis J M, Busuttil R W
Department of Surgery, Dumont-UCLA Transplant Center 90024-1749.
Am Surg. 1993 Dec;59(12):806-12.
Between February 1984 and July 1992, six adults with advanced pancreatic adenocarcinoma (n = 1), pancreatic neuroendocrine tumor (n = 2), and cholangiocarcinoma (n = 3) underwent radical foregut resections (n = 3) or radical pancreaticoduodenectomy (n = 3) combined with liver transplantation. The major postoperative complications included diarrhea (n = 4), pancreaticojejunostomy leak (n = 3), infection (n = 7), malnutrition (n = 3), refractory ascites (n = 2), and late hepatic artery thrombosis (n = 1). Tumor recurrence occurred in one patient. The actuarial survival for the group is 82 per cent at 1 year and 55 per cent at 2 years. The results demonstrate that radical pancreaticoduodenectomy/foregut resections combined with liver transplantation offer potential surgical cure of malignancies involving these organs. However, the procedure is formidable, with frequent complications.
1984年2月至1992年7月期间，6例患有晚期胰腺腺癌（n = 1）、胰腺神经内分泌肿瘤（n = 2）和胆管癌（n = 3）的成人接受了根治性前肠切除术（n = 3）或根治性胰十二指肠切除术（n = 3）并联合肝移植。术后主要并发症包括腹泻（n = 4）、胰空肠吻合口漏（n = 3）、感染（n = 7）、营养不良（n = 3）、难治性腹水（n = 2）和晚期肝动脉血栓形成（n = 1）。1例患者出现肿瘤复发。该组患者1年的精算生存率为82%，2年为55%。结果表明，根治性胰十二指肠切除术/前肠切除术联合肝移植为涉及这些器官的恶性肿瘤提供了潜在的手术治愈方法。然而，该手术难度大，并发症频发。
