Möller E, Schmitt R
Med Klin. 1976 Oct 22;71(43):1831-5.
89 randomized liver patients (42 with chronic hepatitis, 25 with hepatic cirrhosis, 14 with hepatitis of protracted evolution, 8 with alcohol-toxic adiposis hepatica, stage II) are reported, in whom considerable functionally and histologically identifiable therapeutic results were achieved by combined i.v. and oral treatment with thioctic acid. According to expectation, the most favourable results were found in alcohol-conditioned chronic liver diseases; however, also in chronic active hepatitis, resistant to treatment, a therapy could be promising. The oral therapy with thioctic acid, producing no side effects, is especially suited for the long-term outpatient treatment of chronic hepatitis and hepatic cirrhosis of toxic and posthepatic etiology.
报告了89例随机选取的肝病患者（42例慢性肝炎、25例肝硬化、14例迁延性肝炎、8例酒精性脂肪性肝炎II期），通过硫辛酸静脉注射和口服联合治疗，在这些患者身上取得了显著的功能和组织学可识别的治疗效果。正如预期的那样，在酒精性慢性肝病中发现了最有利的结果；然而，对于难治性慢性活动性肝炎，这种治疗方法也可能很有前景。硫辛酸口服治疗无副作用，特别适合于对中毒性和肝后性病因的慢性肝炎和肝硬化进行长期门诊治疗。
