Jahangir S M, Islam F, Chowdhury S N, Aziz L, Ghani M A
Dhaka Medical College Hospital.
Bangladesh Med Res Counc Bull. 1993 Apr;19(1):21-7.
Ketamine, most often used as an anaesthetic agent can provide adequate post operative analgesia when delivered in the form of infusion, replacing narcotics, which can cause bronchospasm in susceptible individuals. This cohort study was undertaken to assess the feasibility of providing complete post operative analgesia in asthmatics with ketamine delivered in sub-anaesthetic doses (6.10-6.41 ugm./kg.-1/min-1). Diazepam (0.97-1.02 ugm./kg.-1/min-1) was delivered from the same infusion to eliminate the unwanted effects of ketamine. Ketamine induced little alteration in blood pressure while tachycardia was significant (P < 0.05). Respiratory functions observed, were favourable for asthmatics. Diazepam helped in reducing ketamine induced side effects, but after infusion over long periods tendency of cumulation was observed. Complications encountered were minimum with more than 93% patient acceptability for this method of analgesia.
氯胺酮最常被用作麻醉剂，以输注形式给药时可提供充分的术后镇痛，从而替代可能在易感个体中引起支气管痉挛的麻醉性镇痛药。本队列研究旨在评估以亚麻醉剂量（6.10 - 6.41微克/千克/分钟）给予氯胺酮，为哮喘患者提供完全术后镇痛的可行性。地西泮（0.97 - 1.02微克/千克/分钟）通过同一输注给药以消除氯胺酮的不良影响。氯胺酮对血压影响较小，而心动过速显著（P < 0.05）。观察到的呼吸功能对哮喘患者有利。地西泮有助于减少氯胺酮引起的副作用，但长时间输注后观察到有累积倾向。遇到的并发症最少，超过93%的患者接受这种镇痛方法。
