Baron B W, Glagov S, Giddens D P, Zarins C K
Department of Pathology, University of Chicago, IL.
Atherosclerosis. 1993 Aug;102(1):37-49. doi: 10.1016/0021-9150(93)90082-6.
Cynomolgus monkeys were fed an atherogenic diet for 6 months following surgically produced high-grade (n = 10) or mild (n = 16) mid-thoracic aortic coarctation. A diet-control (DC) group (n = 13) was fed the diet without coarctation. High-grade coarctation (HGC) resulted in 74.1% +/- 8.3% stenosis by aortography prior to sacrifice and was associated with systolic brachial blood pressures of 143.3 +/- 26.0 mmHg and gradients across the stenoses of 36.8 +/- 23.6 mmHg. Mild coarctation (MC) resulted in stenoses of 50.9% +/- 12.9%, brachial systolic pressures of 119.4 +/- 25.7 and gradients of 12.5 +/- 15.2 mm Hg (P < 0.01, P = 0.03 and P < 0.005, respectively, compared with HGC). When total plaque cross-sectional area exceeded 0.8 mm2, the entire arterial circumference was usually involved. HGC resulted in complete sparing or minimal plaque formation in sections distal to the stenoses compared with proximal sections (P < 0.001). There were no significant differences between MC and DC animals in plaque location or size. Matrix content increased with plaque area regardless of degree of stenosis or sampling level (P < 0.01), but lesions with more than 75% matrix content were more numerous in distal than in proximal sections despite their smaller size. The number of plaques with greater than 75% matrix content was increased proximal to HGC (P < 0.04). Thus, distal location and plaque size were independent determinants of plaque matrix content and matrix content was increased proximal to HGC regardless of plaque size. Attempts to evaluate effects of various regimens and interventions on plaque composition need to take location and plaque size, as well as blood pressure differences, into account.
对食蟹猴进行手术造成中胸段主动脉高度狭窄（n = 10）或轻度狭窄（n = 16），之后给予致动脉粥样化饮食6个月。饮食对照组（DC，n = 13）未进行主动脉缩窄，仅给予该饮食。在处死前通过主动脉造影显示，高度狭窄组（HGC）的狭窄率为74.1%±8.3%，其肱动脉收缩压为143.3±26.0 mmHg，狭窄处压力阶差为36.8±23.6 mmHg。轻度狭窄组（MC）的狭窄率为50.9%±12.9%，肱动脉收缩压为119.4±25.7 mmHg，压力阶差为12.5±15.2 mmHg（与HGC组相比，P分别<0.01、P = 0.03和P<0.005）。当总斑块横截面积超过0.8 mm²时，整个动脉圆周通常都会受累。与近端切片相比，HGC组在狭窄远端的切片中完全没有斑块形成或仅有极少的斑块形成（P<0.001）。MC组和DC组动物在斑块位置或大小方面没有显著差异。无论狭窄程度或取样水平如何，基质含量均随斑块面积增加而增加（P<0.01），但基质含量超过75%的病变在远端切片中比近端切片中更多，尽管其尺寸较小。基质含量超过75%的斑块数量在HGC近端增加（P<0.04）。因此，远端位置和斑块大小是斑块基质含量的独立决定因素，且无论斑块大小如何，HGC近端的基质含量都会增加。评估各种治疗方案和干预措施对斑块成分的影响时，需要考虑位置、斑块大小以及血压差异。
