Pendleton R G, Gessner G, Jenkins B
Naunyn Schmiedebergs Arch Pharmacol. 1976 Nov;295(2):127-33. doi: 10.1007/BF00499444.
Chronic administration of SK&F 64139, an inhibitor of phenylethanolamine N-methyltransferase (PNMT), initially resulted in a lowered adrenal epinephrine content in both the rat and squirrel monkey adrenal gland. With continued dosing, however, these levels returned toward control. The latter changes were accompanied by increased adrenal levels of norepinephrine and PNMT, but not by decreased plasma drug levels. These results suggest that long-term pharmacological PNMT inhibition may evoke compensatory mechanisms to maintain adrenal epinephrine biosynthesis under basal laboratory conditions.
长期给予苯乙醇胺N-甲基转移酶（PNMT）抑制剂SK&F 64139，最初会导致大鼠和松鼠猴肾上腺中肾上腺素含量降低。然而，持续给药后，这些水平又恢复到对照水平。后一种变化伴随着肾上腺中去甲肾上腺素和PNMT水平的升高，但血浆药物水平并未降低。这些结果表明，在基础实验室条件下，长期药理抑制PNMT可能会引发代偿机制以维持肾上腺肾上腺素的生物合成。
