Alia G, Mattaliano A
Servizio di Rianimazione e Terapia Intensiva, U.S.L. 58, Ospedale Civico di Palermo.
Clin Ter. 1993 Oct;143(4):295-301.
The authors report on the use of nimodipine in 36 patients for coma due to severe cerebral (20 haemorrhagic, 2 ischaemic, 9 post-anoxic, 4 traumatic, 1 neoplastic) lesions. In addition to resuscitative therapy, all patients were given nimodipine per os, 60 mg every 4 hrs for 21 days. In all patients, survival, duration of the coma and degree of disability, according G.O.S., were evaluated. Decrease of mortality was highly significant, decrease of disability of surviving patients was significant if compared with comatose patients suffering from similar diseases, but not treated with nimodipine.
作者报告了36例因严重脑部病变（20例出血性、2例缺血性、9例缺氧后、4例创伤性、1例肿瘤性）导致昏迷的患者使用尼莫地平的情况。除复苏治疗外，所有患者均口服尼莫地平，每4小时60毫克，共21天。对所有患者的生存情况、昏迷持续时间和根据格拉斯哥预后评分（G.O.S.）评估的残疾程度进行了评估。死亡率的降低非常显著，与患有相似疾病但未接受尼莫地平治疗的昏迷患者相比，存活患者的残疾程度降低显著。
