Frelinger J A, Hibbler F J, Hill S W
J Immunol. 1978 Dec;121(6):2376-80.
Ia antigens from specific subregions have been examined on functional B cell populations. Expression of both I-A and I-E,C region antigens was demonstrated on cells required for both lipopolysaccharide mitogenesis and polyclonal activation. Similar I-A and I-E,C subregion expression was found on cells required for response to the T-independent antigen, polyvinylpyrrolidone. TNP-specific IgM and hen egg lysozyme-specific IgG plaque-forming cells also express I-A and I-E,C region antigens. No evidence was found for an Ia- population responsive in the systems tested. Further, no evidence of preferential expression of I-A or I-E,C region antigens was observed in any system examined. Therefore, it appears that B cells express both I-A and I-E,C region-coded Ia antigens.
已在功能性B细胞群体上检测了来自特定亚区的Ia抗原。在脂多糖促细胞分裂作用和多克隆激活所需的细胞上均证实了I-A和I-E、C区抗原的表达。在对非T细胞依赖性抗原聚乙烯吡咯烷酮作出反应所需的细胞上发现了类似的I-A和I-E、C亚区表达。TNP特异性IgM和鸡蛋清溶菌酶特异性IgG空斑形成细胞也表达I-A和I-E、C区抗原。在所测试的系统中未发现Ia阴性群体有反应的证据。此外，在任何所检测的系统中均未观察到I-A或I-E、C区抗原优先表达的证据。因此，似乎B细胞表达I-A和I-E、C区编码的Ia抗原。
