Yoshitake T, Takahama T, Kanai F, Ohnishi K, Suzuki T, Kametani Y, Itoyama S, Sugawara I, Matsunaga A
Department of Surgery, Saitama Medical Center, Saitama Medical School, Japan.
Kyobu Geka. 1993 Dec;46(13):1083-7; discussion 1087-9.
Immunohistochemical studies using antibodies to B lymphocyte and to immunoglobulin G bearing cell were carried out for resected thymus-specimens of 10 patients associated with myasthenia gravis. In each case, abundant B cells (L26 positive cell) resided in the follicles and the medulla of thymus, especially, were congregated in the follicles developing germinal center and around Hassall's corpuscles. Amount of B cell population was various among each case regardless of type of myasthenia gravis or age. B cells were greatly increased in the thymus of patients with values of anti-acetylcholine receptor antibody titers over 100 nmol/l. Although numerous B cells were present in the thymus of these patients, IgG bearing cells were extremely rare. In the most cases, B cells lacked IgG expression. From the results, numerous B cells pre-activating autoimmune antibody production were accumulated in the thymus of patients associated with myasthenia gravis.
对10例重症肌无力患者切除的胸腺标本进行了免疫组织化学研究，使用针对B淋巴细胞和携带免疫球蛋白G细胞的抗体。在每例病例中，丰富的B细胞（L26阳性细胞）存在于胸腺的滤泡和髓质中，尤其是聚集在生发中心发育的滤泡和哈氏小体周围。无论重症肌无力的类型或年龄如何，每例病例中的B细胞数量各不相同。抗乙酰胆碱受体抗体滴度值超过100 nmol/l的患者胸腺中B细胞大量增加。虽然这些患者的胸腺中有大量B细胞，但携带IgG的细胞极其罕见。在大多数情况下，B细胞缺乏IgG表达。根据这些结果，在重症肌无力患者的胸腺中积累了大量预激活自身免疫抗体产生的B细胞。
