Abel H T, Von Rohden L, Lamme W, Korb C, Zinsmeyer J, Köditz H, Gross J
Frühgeborenenzentrum, Klinik für Kinderheilkunde, Medizinischen Akademie, Magdeburg, Germany.
Padiatr Grenzgeb. 1993;31(3):133-40.
In a prospective study 199 risk newborn infants were examined by means of cerebral ultrasound scanning and after this the influence of diagnosed intracerebral events on the concentration of neuron-specific enolase (NSE) was determined. The NSE may be valid as an indicator of intracerebral damage. A significant relationship between increased concentration of NSE and intracerebral haemorrhage of type II could be found only for the NSE-1 (determination from cordblood or from blood of the first or second day of life). The same relationship results for intracranial cystic rebuildings, destructions and enlargements of ventricles. The diagnostic tests of NSE-1 for intracerebral haemorrhages don't prove with a validity of 57.4% high prognostic value. Not until a NSE-1-level of 16.0 micrograms/l a predictive value of the positive test of 100% was calculated.
在一项前瞻性研究中，对199名高危新生儿进行了脑部超声扫描检查，之后测定了诊断出的脑内病变对神经元特异性烯醇化酶（NSE）浓度的影响。NSE可能作为脑损伤的一个有效指标。仅对于NSE-1（从脐带血或出生后第一天或第二天的血液中测定），可发现NSE浓度升高与II型脑内出血之间存在显著关系。对于颅内囊性重建、脑室破坏和扩大也有同样的关系。NSE-1对脑内出血的诊断试验未证明具有57.4%的高预后价值。直到NSE-1水平达到16.0微克/升时，阳性试验的预测价值才计算为100%。
