Sakuma H, O'Sullivan M, Lucas J, Wendland M F, Saeed M, Dulce M C, Watson A, Bleyl K L, LaFrance N D, Higgins C B
Department of Radiology, University of California, San Francisco 94343-0628.
Radiology. 1994 Jan;190(1):161-6. doi: 10.1148/radiology.190.1.8259398.
To show the effect of dysprosium diethylenetriaminepentaacetic acid bis-methylamine injection on the images of normal human myocardium.
T2-sensitive fast gradient-recalled echo (GRE) (repetition time [TR], 10.8 msec; echo time [TE], 4.2 msec) and spin-echo (SE) (TR, three RR intervals; TE, 60 msec) magnetic resonance (MR) imaging with driven equilibrium-preparation pulse was used to produce T2 contrast material enhancement. The contrast agent was injected into 12 healthy subjects at doses of 0.05, 0.1, 0.2, 0.4, and 0.6 mmol/kg.
Driven equilibrium-prepared GRE images showed a transient decrease of myocardial signal intensity at doses of 0.2-0.6 mmol/kg. Postcontrast T2-weighted SE images showed a myocardial signal attenuation (30%-45% decrease) at a dose of 0.4 mmol/kg or higher.
Dynamic MR imaging with a magnetic susceptibility contrast medium can be used to monitor the first pass of contrast media through human myocardium with a conventional MR imager and a fast GRE sequence.
展示钆喷酸双甲胺注射液对正常人心肌图像的影响。
采用驱动平衡准备脉冲的T2敏感快速梯度回波（GRE）（重复时间[TR]，10.8毫秒；回波时间[TE]，4.2毫秒）和自旋回波（SE）（TR，三个RR间期；TE，60毫秒）磁共振（MR）成像来产生T2对比剂增强。将对比剂以0.05、0.1、0.2、0.4和0.6 mmol/kg的剂量注入12名健康受试者体内。
驱动平衡准备的GRE图像显示，在0.2 - 0.6 mmol/kg剂量下心肌信号强度短暂降低。对比剂注射后T2加权SE图像显示，在0.4 mmol/kg或更高剂量下心肌信号衰减（降低30% - 45%）。
使用磁共振成像对比剂进行动态MR成像，可通过传统MR成像仪和快速GRE序列监测对比剂首次通过人体心肌的情况。
