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具有抗伤害感受活性的酰胺和甲脒(注释II)。

Amides and formamidines with antinociceptive activity (note II).

作者信息

Pau A, Boatto G, Cerri R, Palomba M, Nicolai M, Sparatore F, Varoni M V

机构信息

Istituto di Analitica Farmaceutica, Università di Sassari, Italy.

出版信息

Farmaco. 1993 Sep;48(9):1291-9.

PMID:8259986
Abstract

Forty amides, formamidines and trifluoromethylsulfonylamides bearing on the nitrogen a cyclohexyl residue, eventually 2-substituted, were prepared and tested for analgesic activity against a chemical stimulus. Good activity was exhibited by amides 9, 11 and 28, by formamidine 34, as well as by triflyamide 40. Eleven additional compounds exhibited a moderate activity.

摘要

制备了40种氮上带有环己基残基(最终为2-取代)的酰胺、甲脒和三氟甲基磺酰胺,并针对化学刺激测试了其镇痛活性。酰胺9、11和28、甲脒34以及三氟甲磺酰胺40表现出良好的活性。另外11种化合物表现出中等活性。

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