Partanen S, Penttilä O, Kyösola K, Merikallio E, Siltanen P
Virchows Arch A Pathol Anat Histol. 1976 Jul 21;370(4):291-6. doi: 10.1007/BF00445774.
The present work was undertaken in order to study the role of monoamine oxidase (MAO) enzyme in the genesis of altered cardiac noradrenalin level in the human heart in various underlying pathologic conditions. The histochemical localization and the activity of MAO were studied in the right atrial appendage of man in ischemic heart disease, in valvular heart disease without or with congestive myocardial failure, and in hearts with an uncomplicated atrial septal defect. MAO was found to be localized mainly extraneuronally in the muscle cells, a little activity was detected in the connective tissue spaces, and nerves reacting positively were tentatively identified. There were no significant differences in MAO activity measured photometrically between the various heart disease groups. It seems that MAO activity measured photometrically between the various heart disease groups. It seems that MAO enzyme plays only a small or no role in the genesis of the latered noradrenalin level in the human heart observed in ischemic heart disease or congestive cardiac failure.
开展本研究是为了探讨单胺氧化酶（MAO）在各种潜在病理状况下人类心脏中去甲肾上腺素水平改变的发生过程中所起的作用。对患有缺血性心脏病、伴有或不伴有充血性心肌衰竭的瓣膜性心脏病以及无并发症房间隔缺损的患者的右心耳，进行了MAO的组织化学定位及活性研究。发现MAO主要定位于肌肉细胞的神经元外，在结缔组织间隙检测到少量活性，并初步鉴定出呈阳性反应的神经。各心脏病组间通过光度法测得的MAO活性无显著差异。似乎在缺血性心脏病或充血性心力衰竭中观察到的人类心脏中去甲肾上腺素水平改变的发生过程中，MAO酶仅起很小的作用或不起作用。
