Gross M
Royal and East Surrey Neurology Research Unit, Royal Surrey County Hospital, Guildford.
Br J Clin Pract. 1993 Jul-Aug;47(4):205-7.
Sumatriptan is a selective agonist of 5-hydroxytryptamine receptors, recommended for the acute treatment of migraine. The 5-HT1 receptor subtype is found in the cranial vasculature of many species including humans, and causes vasoconstriction of these vessels. Sumatriptan as a highly potent 5-HT1 agonist selectively constricts large intracranial blood vessels and also blocks neurogenic inflammation. Those treating patients with severe or inconveniently timed attacks will find sumatriptan the drug of choice.
舒马曲坦是5-羟色胺受体的选择性激动剂，推荐用于偏头痛的急性治疗。5-HT1受体亚型存在于包括人类在内的许多物种的颅脑血管系统中，并可引起这些血管的收缩。舒马曲坦作为一种高效的5-HT1激动剂，可选择性地收缩颅内大血管，并阻断神经源性炎症。对于治疗发作严重或发作时间不方便的患者，舒马曲坦将是首选药物。
