Hartley A L, Blair V, Harris M, Birch J M, Banerjee S S, Freemont A J, McClure J, McWilliam L J
Cancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.
Br J Cancer. 1993 Dec;68(6):1243-6. doi: 10.1038/bjc.1993.512.
Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. Very few patients were aged under 60 years at diagnosis of both their malignancies. The youngest was a known case of neurofibromatosis and, although seven patients were diagnosed with a sarcoma and carcinoma of the breast--a combination of cancers characteristic of the Li-Fraumeni cancer family syndrome--no other patients could directly be identified as suffering from any other cancer predisposition syndrome.
在一项为期三年、基于人群的研究中,对来自英格兰西北部、经组织病理学同行评审的肉瘤患者进行调查,以观察所出现的肿瘤模式。该研究纳入的310名患者中,共有30名患者患有其他原发性肿瘤。在诊断出两种恶性肿瘤时,很少有患者年龄低于60岁。最年轻的患者是一名已知的神经纤维瘤病患者,尽管有7名患者被诊断出患有肉瘤和乳腺癌(这是李-弗劳梅尼癌症家族综合征特有的癌症组合),但无法直接确定其他患者患有任何其他癌症易感综合征。