Brox A, Shustik C
Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, Canada.
Leuk Lymphoma. 1993 Oct;11(3-4):165-71. doi: 10.3109/10428199309086992.
Although the spleen is frequently involved in disseminated non-Hodgkin's lymphoma (NHL), splenic presentation as the initial or only site of disease is uncommon. The true incidence of splenic lymphoma is difficult to estimate because of the variable definition of this disease, however, the diagnosis of primary lymphoma of the spleen should be limited to involvement of only the spleen and splenic hilum. Using this restricted definition, our experience suggests that the prognosis of NHL of the spleen, when pathologically staged, may have a favorable prognosis which approximates that seen with limited stage NHL at other sites. The influence of pathologic subtype on natural history and the impact of adjuvant therapy are discussed.
尽管脾脏常累及播散性非霍奇金淋巴瘤（NHL），但脾脏作为疾病的初始或唯一部位表现并不常见。由于该疾病定义的多变性，脾脏淋巴瘤的真实发病率难以估计，然而，原发性脾脏淋巴瘤的诊断应仅限于仅累及脾脏和脾门。根据这一严格定义，我们的经验表明，经病理分期的脾脏NHL预后可能较好，近似于其他部位局限性NHL的预后。本文讨论了病理亚型对自然病程的影响以及辅助治疗的作用。
