随着溃疡愈合，胃黏膜层粘连蛋白受体表达增强。
Enhancement in gastric mucosal laminin receptor expression with ulcer healing.
作者信息
Piotrowski J, Czajkowski A, Yotsumoto F, Slomiany A, Slomiany B L
机构信息
Research Center, University of Medicine and Dentistry of New Jersey, Newark 07103-2400.
出版信息
Biochem Mol Biol Int. 1993 Sep;31(1):105-12.
The expression of gastric mucosal laminin receptor with chronic ulcer healing was investigated. The receptor protein was isolated from gastric epithelial cell membrane of rats at various stages of ulcer healing and following radioiodination incorporated into vesicles which exhibited specific affinity towards laminin-coated surface. The binding assays revealed that the ulcer healing was accompanied by an increase in laminin receptor expression. A significant increase (2.5-fold) in the receptor expression occurred by the third day following the development of ulcer, reached a maximum of 8.6-fold increase by the 14th day when the ulcer was virtually healed, and its high level remained for at least 20 days. The results demonstrate the importance of laminin receptor as an indice of gastric mucosal repair in ulcer healing.
研究了慢性溃疡愈合过程中胃黏膜层粘连蛋白受体的表达情况。从溃疡愈合不同阶段的大鼠胃上皮细胞膜中分离出该受体蛋白，经放射性碘化后掺入对层粘连蛋白包被表面具有特异性亲和力的囊泡中。结合试验表明，溃疡愈合伴随着层粘连蛋白受体表达的增加。溃疡形成后第三天，受体表达显著增加（2.5倍），在溃疡基本愈合的第14天达到最大增加8.6倍，且其高水平至少维持20天。结果表明层粘连蛋白受体作为溃疡愈合中胃黏膜修复指标的重要性。
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