Greene E, Naranjo J N
Behav Brain Res. 1986 Feb;19(2):123-31. doi: 10.1016/0166-4328(86)90010-0.
The contribution of structures in the limbic diencephalon to spatial memory function was investigated. Rats with lesions of either the anteroventral thalamus, anteromedial thalamus, dorsomedial thalamus or mammillary bodies were compared in their ability to perform a delayed alternation task. The results indicate the ablation of the thalamic nuclei did not impair delayed-alternation memory, but there was impairment following damage to the mammillary bodies. Placement of the discrete lesions was verified using Nissl sections and by tracing the pattern of projections using a silver degeneration stain. The results suggest that individual thalamic nuclei are not essential in the storage and/or retrieval of spatial memory. The data are discussed in terms of spatial deficits resulting from damage to the hippocampus proper or to the pathways connecting it to other brain structures.
研究了边缘间脑中的结构对空间记忆功能的贡献。比较了前腹侧丘脑、前内侧丘脑、背内侧丘脑或乳头体受损的大鼠执行延迟交替任务的能力。结果表明，丘脑核的切除并未损害延迟交替记忆，但乳头体受损后会出现损害。使用尼氏切片并通过银染变性追踪投射模式来验证离散损伤的位置。结果表明，单个丘脑核在空间记忆的存储和/或检索中并非必不可少。根据海马本身或连接它与其他脑结构的通路受损导致的空间缺陷对数据进行了讨论。
