Rosenthale M E, Dervinis A, Strike D
Adv Prostaglandin Thromboxane Res. 1976;1:477-93.
Experimental data now strongly suggest that the PGs, by nature of their natural local occurrence and destruction, powerful effects on, and release from lung tissue are important in regulating both pulmonary homeostasis and dysfunction. Laboratory studies on their activity, potency, duration, preferred route of administration, mechanism and possible antiallergic effects, have been largely substantiated in humans. Structure activity studies on a large number of congeners of PGE, PGF, and PGA emphasize the critical importance of stereochemistry and various substituent groups on biologic activity in the lung.
实验数据现在有力地表明，前列腺素因其在局部天然存在和降解的特性，对肺组织具有强大作用并能从肺组织释放，这在调节肺内稳态和功能障碍方面很重要。关于其活性、效力、持续时间、首选给药途径、作用机制和可能的抗过敏作用的实验室研究，在人体中已基本得到证实。对大量前列腺素E、前列腺素F和前列腺素A同系物的构效关系研究强调了立体化学和各种取代基对肺生物活性的至关重要性。
