Messori A, Rampazzo R
Pharmaceutical Service, University Hospital Policlinico Borgo Roma, Verona, Italy.
Comput Methods Programs Biomed. 1993 Aug;40(4):261-7. doi: 10.1016/0169-2607(93)90011-9.
Meta-analysis is increasingly being used in clinical research. While the meta-analytical algorithms for pooling the results of studies using non-censored end-points are now sufficiently standardized, the management of trials based on censored end-points is still controversial, and specific algorithms of meta-analysis are still needed (for example, censored end-points are commonly used in survival studies of cancer patients). In the present article we review the various algorithms that have thus far been utilized to perform a meta-analysis based on censored end-points, and we propose a new and original approach that combines two of the existing algorithms. Our approach is designed to formulate any meta-analysis of survival studies in terms of the calculation of an odds ratio. The meta-analytical odds ratio proposed here is called the 'log-rank' odds ratio of meta-analysis. A microcomputer program is described that implements the various methods of meta-analysis that can handle clinical trials based on censored end-points. Some examples are presented to illustrate the use of the program.
荟萃分析在临床研究中的应用日益广泛。虽然用于汇总使用非删失终点的研究结果的荟萃分析算法现已充分标准化，但基于删失终点的试验管理仍存在争议，仍需要特定的荟萃分析算法（例如，删失终点常用于癌症患者的生存研究）。在本文中，我们回顾了迄今为止用于基于删失终点进行荟萃分析的各种算法，并提出了一种结合现有两种算法的新颖原创方法。我们的方法旨在根据比值比的计算来制定生存研究的任何荟萃分析。这里提出的荟萃分析比值比称为荟萃分析的“对数秩”比值比。描述了一个微机程序，该程序实现了可以处理基于删失终点的临床试验的各种荟萃分析方法。给出了一些例子来说明该程序的使用。
