Hofmeyr J H, van der Merwe K J
Department of Biochemistry, University of Stellenbosch, South Africa.
Comput Appl Biosci. 1986 Dec;2(4):243-9. doi: 10.1093/bioinformatics/2.4.243.
METAMOD, a BBC microcomputer-based software package for steady-state modelling and control analysis of model metabolic pathways, is described, The package consists of two programs. METADEF allows the user to define the pathway in terms of reactions, rate equations and initial concentrations of metabolites. METACAL uses one of two algorithms to calculate the steady-state concentrations and fluxes. One algorithm uses the current ratio of production and consumption rates of variable metabolites to adjust iteratively their concentrations in such a way that they converge towards the steady state. The other algorithm solves the roots of the system equations by means of a quasi-Newtonian procedure. Control analysis allows the calculation of elasticity, control and response coefficients, by means of finite difference approximation. METAMOD is interactive and easy to use, and suitable for teaching and research purposes.
介绍了METAMOD，这是一个基于BBC微型计算机的软件包，用于模型代谢途径的稳态建模和控制分析。该软件包由两个程序组成。METADEF允许用户根据反应、速率方程和代谢物的初始浓度来定义途径。METACAL使用两种算法之一来计算稳态浓度和通量。一种算法使用可变代谢物的生成速率和消耗速率的当前比率，以迭代方式调整它们的浓度，使其趋向于稳态。另一种算法通过拟牛顿法求解系统方程的根。控制分析允许通过有限差分近似来计算弹性、控制和响应系数。METAMOD具有交互性且易于使用，适用于教学和研究目的。
