Pierson J C, Camisa C, Lawlor K B, Elston D M
Department of Dermatology, Cleveland Clinic Foundation, Ohio.
Cutis. 1993 Oct;52(4):221-2.
A middle-aged woman with common variable immunodeficiency noted a papular skin eruption that simulated Gottron's sign of dermatomyositis on the dorsal hands. Examination of a skin biopsy specimen demonstrated noninfectious granulomatous inflammation. The patient was subsequently found to have visceral granulomas when examined using laparotomy. Noninfectious granulomas of the viscera and integument have been previously reported in patients with several immunodeficiency syndromes, including common variable immunodeficiency.
一名患有常见可变免疫缺陷的中年女性注意到双手背部出现了类似皮肌炎Gottron征的丘疹性皮疹。对皮肤活检标本的检查显示为非感染性肉芽肿性炎症。随后在剖腹探查时发现该患者有内脏肉芽肿。内脏和体表的非感染性肉芽肿此前已在包括常见可变免疫缺陷在内的几种免疫缺陷综合征患者中报道过。
