Huglo D, Rousseaux M, Leys D, Fialdes P, Steinling M
Department of Nuclear Medicine, Hopital Huriez, CHRU of Lille, France.
J Cereb Blood Flow Metab. 1994 Jan;14 Suppl 1:S76-83.
The aim of this study was to compare 99mTc-bicisate with 133Xe inhalation in regional CBF (rCBF) imaging. Five healthy volunteers and five patients were imaged with both techniques. Regional standardized values (SVs) of 99mTc-bicisate, uptake indexes (UIs), and asymmetry indexes (AIs) were compared quantitatively with, respectively, rCBF, flow indexes (FIs), and AIs. Areas with highest rCBF (sylvian and thalamic areas) appeared to be underestimated with 99mTc-bicisate, but significant correlations were found between SV and rCBF (n = 140, r = 0.468, p < 0.01) and for the 10 subjects between UI and FI and between AIs (p < 0.0001). There are therefore distinct regional differences in the cerebral distinction of 99mTc-bicisate and CBF, particularly in the thalamus and the temporal cortex. It is probable but not yet proved that an underestimation of high flow rates occurs with bicisate.
本研究旨在比较99mTc-比西酯与133Xe吸入用于局部脑血流量（rCBF）成像的情况。对5名健康志愿者和5名患者分别采用这两种技术进行成像。分别将99mTc-比西酯的局部标准化值（SVs）、摄取指数（UIs）和不对称指数（AIs）与rCBF、血流指数（FIs）和AIs进行定量比较。99mTc-比西酯似乎低估了rCBF最高的区域（大脑外侧裂和丘脑区域），但在SV与rCBF之间（n = 140，r = 0.468，p < 0.01）以及10名受试者的UI与FI之间和AI之间发现了显著相关性（p < 0.0001）。因此，99mTc-比西酯与CBF的脑区分存在明显的区域差异，尤其是在丘脑和颞叶皮质。比西酯可能会低估高血流速率，但尚未得到证实。
